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Research AssociateDepartment of Chemistry, Alberta Ingenuity Centre for Carbohydrate Science - Edmonton, Alberta
Job Open: 01-Jul-2009   Job Close: 01-Jun-2010
The Alberta Ingenuity Centre for Carbohydrate Science has a vacancy for a Research Associate specializing in the structural determination of complex carbohydrates by high resolution NMR and detailed studies of their complexes with enzymes and carbohydrate binding proteins. The successful applicant will report to the Centre Director, Dr. David Bundle and perform multidimensional high resolution solution NMR research applied to several of the Centre’s research projects. He/she will be expected to publish with the individual PIs leading relevant Centre projects. Using the Centre’s new 700 MHz spectrometer and with routine access to 500, 600 and 800 spectrometers, the incumbent will help Centre microbiologists in structure determination of cell wall polysaccharides and glycoconjugates derived from bio-engineered bacteria. Other projects will involve solution conformational studies of pyranose and furanose containing glycoconjugates and their interactions with the binding/active sites of antibodies or enzymes employing techniques such as STD NMR and transfer NOE. An ability to multitask and interact with several PIs on more than one project will be an essential component of this position. The successful candidate will have at least 2 years of postdoctoral experience in the development and application of multidimensional solution phase NMR spectroscopy applied to the study of non-covalent biological complexes and structure determination of biomolecules. Specifically, this should include experience in the use of NMR spectroscopy based methods to characterize protein–ligand interactions, and experience in the use of molecular modeling to derive solution structures from NOE or other conformationally dependent NMR parameters. Experience in the production and purification of recombinant proteins and molecular biology tools for the production of mutant proteins is desirable. The salary range is $49,801.00 to $62,257.00 per annum, commensurate with experience. Applications should be submitted by email to Dr. David Bundle (dave.bundle@ualberta.ca), providing a curriculum vitae, list of publications and the names of at least two referees who are able to make informed comments on their career and academic achievements.
 
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