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Post-doctoral PositionUniversity of Toronto Mississauga (UTM) - ,
Job Open: 22-Aug-2010   Job Close: 22-Aug-2011
A postdoctoral position is available for a Canadian Institutes of Health Research funded project in the laboratory of Professor Voula Kanelis at the University of Toronto Mississauga (UTM). The successful candidate will investigate the nucleotide binding domains (NBDs) of the sulfonyl urea receptors (SURs) using biophysical approaches, including NMR spectroscopy. SUR proteins are ABC transporters that form the regulatory subunits of ATP-sensitive potassium (KATP) channels. We are studying the effects of disease-causing mutations in the SUR NBDs on their stability, structure, and interactions with other regions in the SURs and in KATP channels. A Ph.D. in biochemistry or a related discipline is required. Candidates should have experience with protein expression and purification and protein NMR spectroscopy. Located 30 km west of downtown Toronto, The University of Toronto Mississauga ( is a campus of the University of Toronto (, the largest research University in Canada. UTM provides all of the advantages of research at the University of Toronto, while additionally providing a smaller, friendly campus environment in a beautiful natural setting by the Credit river. Our newly renovated and well-equipped laboratory contains all the equipment necessary for protein biochemistry and fluorescence spectroscopy. Other equipment (CD spectrophotometer, isothermal titration calorimeter, differential scanning calorimeter) is available in the Center for Applied Bioscience and Biotechnology at the University of Toronto Mississauga. NMR experiments will be performed primarily on a Varian 600 MHz spectrometer equipped with a cryoprobe at UTM. We also have access to high-field spectrometers located at the University of Toronto NMR facility. Interested applicants should submit their CV, contact information for three references, and a description of previous research experience to Voula Kanelis (

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