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Postdoctoral position in NMR availableHenri Poincaré University, Nancy I - CNRS - ,
Job Open: 01-Sep-2011   Job Close: 30-Nov-2011
A post-doctoral position (initially 2 years, from January 2012) is open in the group of Professor Kira J. Weissman (Equipe Enzymologie Moléculaire et Structurale, Laboratoire AREMS, UMR 7214 CNRS-UHP) at Henri Poincaré University, Nancy I. The group, which is housed in a new, state-of-the art Institute of Biology within the Faculty of Medicine, has access to all equipment available in the UMR (for genetic engineering, molecular and microbiology, protein purification, etc.) as well as to multiple platforms dedicated to structural biology and biophysical chemistry. The overall goal of the ANR-funded project is to study protein-protein interactions in the modular polyketide synthases (PKSs), gigantic multienzyme Œassembly lines‚ responsible for the biosynthesis of numerous natural products of clinical value. The post-doc position requires a PhD in biochemistry, structural biology or a related field. Applicants should have at minimum a good familiarity with all stages of protein structure elucidation by NMR (including experience in cloning, protein expression and purification), and must in addition have expertise in various biophysical methods for studying protein-protein interactions (e.g. SPR and ITC). The candidate should be a motivated individual, who enjoys working in a collaborative environment at the interface of chemistry and biology. Interested candidates should send an up-to-date CV, a statement of research interests, and names (including e-mail addresses) of a minimum of two referees to Prof. Weissman ( Relevant publications: Tran L, Broadhurst RW, Tosin M, Cavalli A& Weissman KJ* (2010) Insights into protein-protein and enzyme-substrate interactions in modular polyketide synthases. Chem Biol. 17, 705-16. Tran L, Tosin M, Spencer JB, Leadlay PF& Weissman KJ* (2008) Covalent linkage mediates communication between ACP and TE domains in modular polyketide synthases. ChemBioChem 9, 905ˆ915. Weissman KJ*& Müller R (2008) Protein-protein interactions in multienzyme megasythetases. ChemBioChem 9, 826ˆ848. Weissman KJ*, Hong H, Popovic B& Meersman F (2006) Evidence for a protein-protein interaction motif on an acyl carrier protein domain from a modular polyketide synthase. Chem. Biol. 13, 625ˆ636.

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