|Postdoctoral position in NMR available||Henri Poincaré University, Nancy I - CNRS - , |
|Job Open: 01-Sep-2011 Job Close: 30-Nov-2011|
|A post-doctoral position (initially 2 years, from January 2012) is open in the
group of Professor Kira J. Weissman (Equipe Enzymologie Moléculaire et
Structurale, Laboratoire AREMS, UMR 7214 CNRS-UHP) at Henri Poincaré
University, Nancy I.
The group, which is housed in a new, state-of-the art Institute of Biology
within the Faculty of Medicine, has access to all equipment available in the
UMR (for genetic engineering, molecular and microbiology, protein purification,
etc.) as well as to multiple platforms dedicated to structural biology and
The overall goal of the ANR-funded project is to study protein-protein
interactions in the modular polyketide synthases (PKSs), gigantic multienzyme
Œassembly lines‚ responsible for the biosynthesis of numerous natural products
of clinical value.
The post-doc position requires a PhD in biochemistry, structural biology or a
related field. Applicants should have at minimum a good familiarity with all
stages of protein structure elucidation by NMR (including experience in
cloning, protein expression and purification), and must in addition have
expertise in various biophysical methods for studying protein-protein
interactions (e.g. SPR and ITC). The candidate should be a motivated
individual, who enjoys working in a collaborative environment at the interface
of chemistry and biology.
Interested candidates should send an up-to-date CV, a statement of research
interests, and names (including e-mail addresses) of a minimum of two referees
to Prof. Weissman (firstname.lastname@example.org).
Tran L, Broadhurst RW, Tosin M, Cavalli A& Weissman KJ* (2010) Insights into
protein-protein and enzyme-substrate interactions in modular polyketide
synthases. Chem Biol. 17, 705-16.
Tran L, Tosin M, Spencer JB, Leadlay PF& Weissman KJ* (2008) Covalent linkage
mediates communication between ACP and TE domains in modular polyketide
synthases. ChemBioChem 9, 905ˆ915.
Weissman KJ*& Müller R (2008) Protein-protein interactions in multienzyme
megasythetases. ChemBioChem 9, 826ˆ848.
Weissman KJ*, Hong H, Popovic B& Meersman F (2006) Evidence for a
protein-protein interaction motif on an acyl carrier protein domain from a
modular polyketide synthase. Chem. Biol. 13, 625ˆ636. |